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Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2015 May 21; Vol. 21 (19), pp. 6018-25. - Publication Year :
- 2015
-
Abstract
- Aim: To evaluate vascular endothelial growth factor (VEGF) and tryptase in hepatocellular cancer (HCC) before and after trans-arterial chemoembolization (TACE).<br />Methods: VEGF and tryptase serum concentrations were assessed from 71 unresectable HCC patients before and after hepatic TACE performed by binding DC-Beads(®) to doxorubicin. VEGF levels were examined for each serum sample using the Quantikine Human VEGF-enzyme-linked immuno-absorbent assay (ELISA), whereas tryptase serum concentrations were assessed for each serum sample by means of fluoro-enzyme immunoassay (FEIA) using the Uni-CAP100 tool. Differences between serum VEGF and tryptase values before and after TACE were evaluated using Student t test. Person's correlation was used to assess the degree of association between the two variables.<br />Results: VEGF levels and serum tryptase in HCC patients before TACE had a mean value and standard deviation (SD) of 114.31 ± 79.58 pg/mL and 8.13 ± 3.61 μg/L, respectively. The mean levels and SD of VEGF levels and serum tryptase in HCC patients after TACE were 238.14 ± 109.41 pg/mL and 4.02 ± 3.03 μg/L. The changes between the mean values of concentration of VEGF and tryptase before treatment and after treatment was statistically significant (P < 0.000231 and P < 0.00124, by Wilcoxon-Mann-Whitney respectively). A significant correlation between VEGF levels before and after TACE and between tryptase levels before and after TACE was demonstrated (r = 0.68, P = 0.003; r = 0.84, P = 0.000 respectively).<br />Conclusion: Our pilot results suggest that the higher serum VEGF levels and the lower tryptase levels following TACE may be potential biomarkers changing in response to therapy.
- Subjects :
- Aged
Aged, 80 and over
Antibiotics, Antineoplastic administration & dosage
Carcinoma, Hepatocellular blood
Carcinoma, Hepatocellular enzymology
Carcinoma, Hepatocellular pathology
Doxorubicin administration & dosage
Female
Humans
Liver Neoplasms blood
Liver Neoplasms enzymology
Liver Neoplasms pathology
Male
Middle Aged
Pilot Projects
Predictive Value of Tests
Prospective Studies
Time Factors
Treatment Outcome
Biomarkers, Tumor blood
Carcinoma, Hepatocellular therapy
Chemoembolization, Therapeutic
Liver Neoplasms therapy
Tryptases blood
Vascular Endothelial Growth Factor A blood
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 21
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 26019468
- Full Text :
- https://doi.org/10.3748/wjg.v21.i19.6018