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Hemoglobin C Trait Provides Protection From Clinical Falciparum Malaria in Malian Children.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2015 Dec 01; Vol. 212 (11), pp. 1778-86. Date of Electronic Publication: 2015 May 27. - Publication Year :
- 2015
-
Abstract
- Background: Hemoglobin C trait, like hemoglobin S trait, protects against severe malaria in children, but it is unclear whether hemoglobin C trait also protects against uncomplicated malaria. We hypothesized that Malian children with hemoglobin C trait would have a lower risk of clinical malaria than children with hemoglobin AA.<br />Methods: Three hundred children aged 0-6 years were enrolled in a cohort study of malaria incidence in Bandiagara, Mali, with continuous passive and monthly active follow-up from June 2009 to June 2010.<br />Results: Compared to hemoglobin AA children (n = 242), hemoglobin AC children (n = 39) had a longer time to first clinical malaria episode (hazard ratio [HR], 0.19; P = .001; 364 median malaria-free days vs 181 days), fewer episodes of clinical malaria, and a lower cumulative parasite burden. Similarly, hemoglobin AS children (n = 14) had a longer time to first clinical malaria episode than hemoglobin AA children (HR, 0.15; P = .015; 364 median malaria-free days vs 181 days), but experienced the most asymptomatic malaria infections of any group.<br />Conclusions: Both hemoglobin C and S traits exerted a protective effect against clinical malaria episodes, but appeared to do so by mechanisms that differentially affect the response to infecting malaria parasites.<br /> (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.)
- Subjects :
- Child
Child, Preschool
Cohort Studies
Female
Hemoglobin, Sickle genetics
Humans
Incidence
Infant
Infant, Newborn
Male
Mali epidemiology
Genetic Predisposition to Disease epidemiology
Genetic Predisposition to Disease genetics
Hemoglobin C genetics
Malaria, Falciparum epidemiology
Malaria, Falciparum genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 212
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26019283
- Full Text :
- https://doi.org/10.1093/infdis/jiv308