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Clinicopathologic features and prognostic factors in patients with non-cutaneous malignant melanoma: a single-center retrospective study of 71 cases.
- Source :
-
International journal of dermatology [Int J Dermatol] 2015 Dec; Vol. 54 (12), pp. 1390-5. Date of Electronic Publication: 2015 May 27. - Publication Year :
- 2015
-
Abstract
- Objectives: This retrospective study was carried out to define the clinical features and prognostic differences in non-cutaneous malignant melanoma (non-CMM) originating from different anatomic sites.<br />Methods: Clinical and follow-up data for 71 patients with non-CMM were collected and reviewed.<br />Results: Of the 71 non-CMM patients, 59 were diagnosed with mucosal malignant melanoma (MMM) and 12 with ocular malignant melanoma (OMM). In the 59 MMM patients, the nasal cavity was the most common anatomic site (n = 31, 43.7% of all non-CMM), followed by the oral cavity (n = 9, 12.7%), the genitourinary tract (n = 9, 12.7%), the anorectum (n = 8, 11.3%), and the gastrointestinal tract (n = 2, 2.8%). In the 12 patients with OMM, anatomic sites included the choroid (n = 8, 11.3% of all non-CMM) and the conjunctiva (n = 4, 5.6%). The survival outcome of patients with OMM was much better than that of patients with MMM (P < 0.001). In MMM patients, anorectal melanoma was associated with a worse survival outcome. Age of ≥ 70 years (P < 0.001) and tumor size of > 2 cm (P = 0.02) were significantly poor prognostic factors in MMM. Age (relative risk [RR] 1.068, 95% confidence interval [CI] 1.006-1.133; P = 0.03) and tumor size (RR 1.410, 95% CI 1.038-1.915; P = 0.028) were independent predictors for the postoperative survival of MMM patients. Patients with these two risk factors had a higher risk for recurrence or death (RR 3.107, 95% CI 1.627-5.595).<br />Conclusions: Our findings demonstrate that prognoses differ in patients with different anatomic sites of primary non-CMM. Advanced age and larger tumor size are the main factors affecting prognosis. Patients with poor risk factors should be treated differently to improve their survival outcome.<br /> (© 2015 The International Society of Dermatology.)
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Choroid Neoplasms pathology
Conjunctival Neoplasms pathology
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Melanoma pathology
Middle Aged
Mouth Neoplasms pathology
Mucous Membrane
Nose Neoplasms pathology
Prognosis
Proportional Hazards Models
Rectal Neoplasms pathology
Retrospective Studies
Survival Rate
Tumor Burden
Urogenital Neoplasms pathology
Choroid Neoplasms mortality
Conjunctival Neoplasms mortality
Melanoma mortality
Mouth Neoplasms mortality
Nose Neoplasms mortality
Rectal Neoplasms mortality
Urogenital Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1365-4632
- Volume :
- 54
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 26016703
- Full Text :
- https://doi.org/10.1111/ijd.12745