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The effects of nicorandil on microvascular function in patients with ST segment elevation myocardial infarction undergoing primary PCI.
- Source :
-
Cardiovascular ultrasound [Cardiovasc Ultrasound] 2015 May 27; Vol. 13, pp. 26. Date of Electronic Publication: 2015 May 27. - Publication Year :
- 2015
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Abstract
- Background: Nicorandil, as a selective potassium channel opener, has dual action including coronary and peripheral vasodilatation and cardioprotective effect through ischemic preconditioning. Considering those characteristics, nicorandil was suggested to reduce the degree of microvascular dysfunction.<br />Methods: Thirty-two patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (pPCI) were included in the study. Index of microvascular resistance (IMR) was measured in all patients immediatelly after pPCI before the after administration of Nicorandil. ST segment resolution was monitored before intervention and 60 min after terminating the procedure. Echocardiographic evaluation of myocardial function and transthoracic Doppler derived Coronary flow reserve (CFR) of infarct related artery (IRA) was performed during hospitalization and 3 months later.<br />Results: IMR was significantly lower after administration of Nicorandil (9.9 ± 3.7 vs. 14.1 ± 5.1, p < 0.001). There was significant difference in ST segment elevation before and after primary PCI with administration of Nicorandil (6.9 ± 3.7 mm vs. 1.6 ± 1.6 mm, p < 0.001). Transthoracic Doppler CFR measurement improved after 3 months (2.69 ± 0.38 vs. 2.92 ± 0.54, p = 0.021), as well as WMSI (1.14 ± 0.17 vs. 1.07 ± 0.09, p = 0.004).<br />Conclusion: Intracoronary Nicorandil administration after primary PCI significantly decreases IMR, resulting in improved CFR and ventricular function in patients with STEMI undergoing primary PCI.
- Subjects :
- Cardiotonic Agents therapeutic use
Coronary Artery Disease etiology
Female
Humans
Male
Middle Aged
Myocardial Infarction complications
Treatment Outcome
Ultrasonography
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease drug therapy
Microcirculation drug effects
Myocardial Infarction diagnostic imaging
Myocardial Infarction drug therapy
Nicorandil therapeutic use
Percutaneous Coronary Intervention methods
Subjects
Details
- Language :
- English
- ISSN :
- 1476-7120
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Cardiovascular ultrasound
- Publication Type :
- Academic Journal
- Accession number :
- 26012474
- Full Text :
- https://doi.org/10.1186/s12947-015-0020-9