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Simkania negevensis and acute cellular rejection in lung transplant recipients.
- Source :
-
Clinical transplantation [Clin Transplant] 2015 Aug; Vol. 29 (8), pp. 705-11. Date of Electronic Publication: 2015 Jul 20. - Publication Year :
- 2015
-
Abstract
- Simkania negevensis infection has been hypothesized to play a role in lung transplant rejection. The incidence of S. negevensis infection and its association with acute cellular rejection (ACR) were determined in a prospective cohort study of 78 lung transplant recipients (LTRs) in Toronto, Canada, and Pittsburgh, USA, from July 2007 to January 2010. Simkania negevensis testing was detected by quantitative polymerase chain reaction (PCR) on bronchoalveolar lavage fluid. The relationship between S. negevensis and ACR was examined using Cox proportional hazards models and generalized linear and latent mixed models. Cumulative incidence estimates for time-to-ACR in S. negevensis PCR-positive vs. PCR-negative LTRs were 52.7% vs. 31.1% at six months and 68.9% vs. 44.6% at one yr, respectively. Although not statistically significant, there was a trend toward a higher risk of ACR among S. negevensis PCR-positive vs. PCR-negative LTRs in all statistical models.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Bronchoalveolar Lavage Fluid microbiology
Canada epidemiology
Chlamydiales genetics
DNA, Bacterial genetics
Female
Follow-Up Studies
Graft Survival
Gram-Negative Bacterial Infections microbiology
Humans
Immunosuppressive Agents therapeutic use
Lung Diseases microbiology
Male
Middle Aged
Prevalence
Prognosis
Prospective Studies
Real-Time Polymerase Chain Reaction
Risk Factors
Transplant Recipients
United States epidemiology
Chlamydiales isolation & purification
Graft Rejection epidemiology
Graft Rejection microbiology
Gram-Negative Bacterial Infections complications
Lung Diseases surgery
Lung Transplantation adverse effects
Postoperative Complications
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 26009941
- Full Text :
- https://doi.org/10.1111/ctr.12571