Back to Search
Start Over
First insights into circulating Mycobacterium tuberculosis complex lineages and drug resistance in Guinea.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2015 Jul; Vol. 33, pp. 314-9. Date of Electronic Publication: 2015 May 21. - Publication Year :
- 2015
-
Abstract
- In this study we assessed first-line anti-tuberculosis drug resistance and the genotypic distribution of Mycobacterium tuberculosis complex (MTBC) isolates that had been collected from consecutive new tuberculosis patients enrolled in two clinical trials conducted in Guinea between 2005 and 2010. Among the total 359 MTBC strains that were analyzed in this study, 22.8% were resistant to at least one of the first line anti-tuberculosis drugs, including 2.5% multidrug resistance and 17.5% isoniazid resistance, with or without other drugs. In addition, further characterization of isolates from a subset of the two trials (n = 184) revealed a total of 80 different spoligotype patterns, 29 "orphan" and 51 shared patterns. We identified the six major MTBC lineages of human relevance, with predominance of the Euro-American lineage. In total, 132 (71.7%) of the strains were genotypically clustered, and further analysis (using the DESTUS model) suggesting significantly faster spread of LAM10&#95;CAM family (p = 0.00016). In conclusion, our findings provide a first insight into drug resistance and the population structure of the MTBC in Guinea, with relevance for public health scientists in tuberculosis control programs.<br /> (Copyright © 2015. Published by Elsevier B.V.)
- Subjects :
- Antitubercular Agents pharmacology
Guinea
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis genetics
Prevalence
Tuberculosis, Multidrug-Resistant epidemiology
Tuberculosis, Multidrug-Resistant microbiology
Tuberculosis, Pulmonary epidemiology
Tuberculosis, Pulmonary microbiology
Bacteremia
Drug Resistance, Microbial
Mycobacterium tuberculosis classification
Mycobacterium tuberculosis drug effects
Tuberculosis epidemiology
Tuberculosis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 33
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26004194
- Full Text :
- https://doi.org/10.1016/j.meegid.2015.05.022