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Eosinophil-rich syphilis: a report of four cases.
- Source :
-
Journal of cutaneous pathology [J Cutan Pathol] 2015 Aug; Vol. 42 (8), pp. 554-8. Date of Electronic Publication: 2015 Jul 03. - Publication Year :
- 2015
-
Abstract
- The differential diagnosis for eosinophil-rich skin lesions often includes a drug reaction, allergic contact dermatitis and rarely, response to a helminth infection. However, many unrelated entities, such as infections, neoplasms and inflammatory dermatoses, can have a prominent eosinophilic infiltrate. Syphilis is classically associated with plasma cells, but other patterns of inflammation have been reported, including ulcerative, granulomatous and eosinophil-rich. Classic teaching might indicate that the presence of eosinophils argues against a diagnosis of syphilis. We present four cases of secondary syphilis with increased eosinophils, ranging from 8 to >200 eosinophils per 10 high-power fields (×400 magnification). Patient 1 had lesions on the penis and scrotum, with greater than 200 eosinophils per 10 high-power fields. Patient 2 had lesions on the back, with 150 eosinophils per 10 high-power fields. Patient 3 had lesions on the bilateral arms, with 8 eosinophils per 10 high-power fields. Patient 4 had lesions involving the anus, with 17 eosinophils per 10 high-power fields. These cases highlight that the presence of an eosinophil-rich infiltrate on skin biopsy should not exclude syphilis from the differential diagnosis.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Biopsy
Diagnosis, Differential
Eosinophilia pathology
Humans
Male
Middle Aged
Skin Diseases blood
Skin Diseases pathology
Syphilis blood
Syphilis drug therapy
Syphilis microbiology
Treponema pallidum isolation & purification
Eosinophilia microbiology
Eosinophils pathology
Skin Diseases microbiology
Syphilis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0560
- Volume :
- 42
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of cutaneous pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25997023
- Full Text :
- https://doi.org/10.1111/cup.12540