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Left Atrial Function in Patients with Chronic Chagasic Cardiomyopathy.

Authors :: Fragata Cda S
Matsumoto AY
Ramires FJ
Fernandes F
Buck Pde C
Salemi VM
Nastari L
Mady C
Ianni BM
Source :: Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2015 Jul; Vol. 105 (1), pp. 28-36. Date of Electronic Publication: 2015 May 08.
Publication Year :: 2015
Abstract: Background: Chagas disease is a cause of dilated cardiomyopathy, and information about left atrial (LA) function in this disease still lacks.<br />Objective: To assess the different LA functions (reservoir, conduit and pump functions) and their correlation with the echocardiographic parameters of left ventricular (LV) systolic and diastolic functions.<br />Methods: 10 control subjects (CG), and patients with Chagas disease as follows: 26 with the indeterminate form (GI); 30 with ECG alterations (GII); and 19 with LV dysfunction (GIII). All patients underwent M-mode and two-dimensional echocardiography, pulsed-wave Doppler and tissue Doppler imaging.<br />Results: Reservoir function (Total Emptying Fraction: TEF): (p <0.0001), lower in GIII as compared to CG (p = 0.003), GI (p <0.001) and GII (p <0.001). Conduit function (Passive Emptying Fraction: PEF): (p = 0.004), lower in GIII (GIII and CG, p = 0.06; GI and GII, p = 0.06; and GII and GIII, p = 0.07). Pump function (Active Emptying Fraction: AEF): (p = 0.0001), lower in GIII as compared to CG (p = 0.05), GI (p<0.0001) and GII (p = 0.002). There was a negative correlation of E/e' (average) with the reservoir and pump functions (TEF and AEF), and a positive correlation of e' (average) with s' wave (both septal and lateral walls) and the reservoir, conduit and pump LA functions.<br />Conclusion: An impairment of LA functions in Chagas cardiomyopathy was observed.