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Vitamin D levels in juvenile idiopathic arthritis from an equatorial region.
- Source :
-
Rheumatology international [Rheumatol Int] 2015 Oct; Vol. 35 (10), pp. 1717-23. Date of Electronic Publication: 2015 May 20. - Publication Year :
- 2015
-
Abstract
- We aimed to describe the serum levels of 25-hydroxyvitamin D (25OHD) in juvenile idiopathic arthritis (JIA) patients living in a low-latitude (3°43'S) region. Fifty JIA patients, 31 (62 %) female, seen between May 2012 and April 2013 in the northeast of Brazil had clinical data and serum collected for determination of 25OHD and parathyroid hormone (PTH) using a chemiluminescent ELISA; 20 age- and sex-matched controls were used for comparison. Mean age was 13.4 ± 4 years. Twenty-five (50 %), 15 (30 %), 4 (8 %), 4 (8 %), and 2 (4 %) patients were of the polyarticular, oligoarticular, systemic, enthesitis-related, and undifferentiated categories, respectively. Mean 25OHD was 31.6 ± 10 and 30.4 ± 5.7 ng/mL in patients and controls (P > 0.05), respectively; PTH was normal in JIA and controls; 25OHD was similar regardless of JIA category, disease activity, or severity measured by JADAS-27, CHAQ, or presence of joint deformities. Twenty-six (52 %), 20 (40 %), and 4 (8 %) patients were considered to have optimal, sufficient, and deficient 25OHD levels, respectively, whereas 11 (52 %) and 10 (48 %) controls had optimal and sufficient 25OHD. Ethnicity, body mass index, seasonal variation, and use of steroids did not influence 25OHD levels. This is the first study on 25OHD levels in JIA patients living in a low-latitude region, showing the lowest prevalence of vitamin D deficiency ever reported. Serum 25OHD was similar in JIA and controls and did not vary regardless of JIA category or severity.
- Subjects :
- Adolescent
Arthritis, Juvenile diagnosis
Brazil epidemiology
Child
Cross-Sectional Studies
Female
Humans
Male
Parathyroid Hormone blood
Prevalence
Seasons
Vitamin D blood
Vitamin D Deficiency blood
Vitamin D Deficiency diagnosis
Arthritis, Juvenile blood
Vitamin D analogs & derivatives
Vitamin D Deficiency epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1437-160X
- Volume :
- 35
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Rheumatology international
- Publication Type :
- Academic Journal
- Accession number :
- 25991398
- Full Text :
- https://doi.org/10.1007/s00296-015-3287-0