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A new cyclolignan glycoside from the tubers of Pinellia ternata.
- Source :
-
Journal of Asian natural products research [J Asian Nat Prod Res] 2015; Vol. 17 (11), pp. 1097-103. Date of Electronic Publication: 2015 May 19. - Publication Year :
- 2015
-
Abstract
- A new 2,7'-type cyclolignan glycoside, cyclolignanyingoside A (1), together with six known compounds (2-7) were isolated from the tubers of Pinellia ternata (Thunb.) Breit. The structure of 1 was elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HR-ESI-MS, and CD spectrometry. The cytotoxic, antioxidant and tyrosinase-inhibiting activities of all the isolates were determined. However, all the isolates exhibited no activity on the selected cell lines (Hep-3B, Bcap-37, and MCF-7). In addition, compounds 1-3 and 7 exhibited strong 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) free radical scavenging activity, and compounds 2 and 4 showed a moderate mushroom tyrsinase inhibitory activity.
- Subjects :
- Agaricales drug effects
Agaricales enzymology
Antioxidants chemistry
Antioxidants pharmacology
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal pharmacology
Glycosides chemistry
Glycosides pharmacology
Lignans chemistry
Lignans pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Tubers chemistry
Antioxidants isolation & purification
Drugs, Chinese Herbal isolation & purification
Glycosides isolation & purification
Lignans isolation & purification
Monophenol Monooxygenase antagonists & inhibitors
Pinellia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2213
- Volume :
- 17
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of Asian natural products research
- Publication Type :
- Academic Journal
- Accession number :
- 25989151
- Full Text :
- https://doi.org/10.1080/10286020.2015.1041931