Predictors of Hypoglycemia in the ASPIRE In-Home Study and Effects of Automatic Suspension of Insulin Delivery.

Authors :: Weiss R
Garg SK
Bergenstal RM
Klonoff DC
Bode BW
Bailey TS
Thrasher J
Schwartz F
Welsh JB
Kaufman FR
Source :: Journal of diabetes science and technology [J Diabetes Sci Technol] 2015 May 18; Vol. 9 (5), pp. 1016-20. Date of Electronic Publication: 2015 May 18.
Publication Year :: 2015
Abstract: Background: Hypoglycemia varies between patients with type 1 diabetes and is the main obstacle to therapy intensification. We investigated known and potential risk factors for hypoglycemia in subjects with type 1 diabetes.<br />Method: In the ASPIRE In-Home study (NCT01497938), a randomized trial of the threshold suspend (TS) feature of sensor-augmented insulin pump (SAP) therapy, subjects' propensity to nocturnal hypoglycemia (NH) was established in a 2-week run-in phase and assessed in a 3-month study phase via continuous glucose monitoring. Categorical variables were tested for association with NH rates in both phases.<br />Results: Elevated rates of NH were significantly associated with baseline A1C ≤7%, with bolus insulin deliveries unassisted by the bolus estimation calculator, and with assignment to the control group during the study phase.<br />Conclusions: Routine use of the TS feature and the bolus estimation calculator are strategies that may reduce the risk of NH.<br /> (© 2015 Diabetes Technology Society.)

Subjects :: Blood Glucose Self-Monitoring
Diabetes Mellitus, Type 1 blood
Female
Humans
Hypoglycemia blood
Hypoglycemic Agents adverse effects
Hypoglycemic Agents therapeutic use
Insulin adverse effects
Insulin therapeutic use
Insulin Infusion Systems
Male
Blood Glucose analysis
Diabetes Mellitus, Type 1 drug therapy
Hypoglycemia chemically induced
Hypoglycemic Agents administration & dosage
Insulin administration & dosage

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