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Insulin therapy in hyperglycemic children with severe acute asthma.
- Source :
-
The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2015 Sep; Vol. 52 (7), pp. 681-6. Date of Electronic Publication: 2015 May 18. - Publication Year :
- 2015
-
Abstract
- Objectives: The aim of this study was to assess the effect of intravenous (IV) insulin administration in children with severe acute asthma (SAA) and hyperglycemia on IV salbutamol consumption and length of stay (LOS) in a pediatric intensive care unit (PICU).<br />Methods: Retrospective, descriptive study of the clinical course before and after implementation of an insulin protocol for the treatment of hyperglycemia (i.e. blood glucose >8 mmol/L or 144 mg/dL, respectively) in the PICU of a tertiary care university hospital. Admissions between 1994 and 2010 were reviewed. The insulin protocol was introduced in 2006.<br />Results: A total of 131 pediatric patients with SAA complicated by hyperglycemia requiring IV salbutamol were included. Severity of illness before and after implementation of the insulin protocol did not significantly differ. The insulin-treated patient group had significantly higher maximum blood glucose levels and higher cumulative IV salbutamol dose than the non-treated group. There were no differences between these groups in the duration of IV salbutamol administration and LOS.<br />Conclusions: In view of the lack of difference in outcomes and considering that the insulin protocol is labor-intensive, the question is whether this protocol is efficacious for the treatment of pediatric SAA associated with hyperglycemia.
- Subjects :
- Acute Disease
Administration, Intravenous
Adolescent
Albuterol administration & dosage
Blood Glucose
Bronchodilator Agents administration & dosage
Child
Child, Preschool
Clinical Protocols
Female
Humans
Hypoglycemic Agents administration & dosage
Infant
Insulin administration & dosage
Intensive Care Units, Pediatric
Male
Retrospective Studies
Severity of Illness Index
Albuterol therapeutic use
Asthma drug therapy
Bronchodilator Agents therapeutic use
Hyperglycemia drug therapy
Hypoglycemic Agents therapeutic use
Insulin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4303
- Volume :
- 52
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of asthma : official journal of the Association for the Care of Asthma
- Publication Type :
- Academic Journal
- Accession number :
- 25982907
- Full Text :
- https://doi.org/10.3109/02770903.2015.1008139