Back to Search
Start Over
Disproportionate fetal growth and the risk for congenital cerebral palsy in singleton births.
- Source :
-
PloS one [PLoS One] 2015 May 14; Vol. 10 (5), pp. e0126743. Date of Electronic Publication: 2015 May 14 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Objective: To investigate the association between proportionality of fetal and placental growth measured at birth and the risk for congenital cerebral palsy (CP).<br />Study Design: We identified all live-born singletons born in Denmark between 1995 and 2003 and followed them from 1 year of age until December 31st, 2008. Information on four indices of fetal growth: ponderal index, head circumference/ abdominal circumference ratio, cephalization index and birth weight/ placenta weight ratio was collected. Cox proportional hazards regression models were used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI). All measurements were evaluated as gestational age and sex specific z-scores and in z-score percentile groups, adjusted for potential confounders, and stratified on gestational age groups (<32, 32-36, 37-38, 39, 40, ≥ 41 weeks).<br />Results: We identified 503,784 singleton births, of which 983 were confirmed cases of CP. Head/ abdominal circumference ratio (aHR:1.12; 95%CI:1.07-1.16) and cephalization index (aHR:1.14; 95%CI:1.11-1.16) were associated with the risk of CP irrespective of gestational age. Birth weight-placental weight ratio was also associated with CP in the entire cohort (aHR:0.90; 95%CI:0.83-0.97). Ponderal index had a u-shaped association with CP, where both children with low and high ponderal index were at higher risk of CP.<br />Conclusions: CP is associated with disproportions between birth weight, birth length, placental weight and head circumference suggesting pre and perinatal conditions contribute to fetal growth restriction in children with CP.
- Subjects :
- Adult
Birth Weight
Cerebral Palsy pathology
Cohort Studies
Denmark epidemiology
Female
Follow-Up Studies
Gestational Age
Head anatomy & histology
Humans
Infant
Infant, Newborn
Male
Placenta anatomy & histology
Placenta physiology
Pregnancy
Proportional Hazards Models
Risk Factors
Smoking
Young Adult
Cerebral Palsy congenital
Cerebral Palsy epidemiology
Fetal Development physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25974407
- Full Text :
- https://doi.org/10.1371/journal.pone.0126743