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Single-side access, isotropic resolution, and multispectral three-dimensional photoacoustic imaging with rotate-translate scanning of ultrasonic detector array.
- Source :
-
Journal of biomedical optics [J Biomed Opt] 2015 May; Vol. 20 (5), pp. 56004. - Publication Year :
- 2015
-
Abstract
- Photoacoustic imaging can achieve high-resolution three-dimensional (3-D) visualization of optical absorbers at penetration depths of ∼1 cm in biological tissues by detecting optically induced high ultrasound frequencies. Tomographic acquisition with ultrasound linear arrays offers an easy implementation of single-side access, parallelized, and high-frequency detection, but usually comes with an image quality impaired by the directionality of the detectors. Indeed, a simple translation of the array perpendicular to its median imaging plane is often used, but results both in a poor resolution in the translation direction and strong limited-view artifacts.To improve the spatial resolution and the visibility of complex structures while retaining a planar detection geometry, we introduce, in this paper, a rotate-translate scanning scheme and investigate the performance ofa scanner implemented at 15 MHz center frequency. The developed system achieved a quasi-isotropic uniform 3-D resolution of ∼170 μm over a cubic volume of side length 8.5 mm, i.e., an improvement in the resolution in the translation direction by almost one order of magnitude. Dual-wavelength imaging was also demonstrated with ultrafast wavelength shifting. The validity of our approach was shown in vitro. We discuss the ability to enable in vivo imaging for preclinical and clinical studies.
- Subjects :
- Anisotropy
Equipment Design
Equipment Failure Analysis
Image Enhancement methods
Image Interpretation, Computer-Assisted methods
Lasers
Phantoms, Imaging
Reproducibility of Results
Rotation
Sensitivity and Specificity
Image Enhancement instrumentation
Image Interpretation, Computer-Assisted instrumentation
Imaging, Three-Dimensional instrumentation
Photoacoustic Techniques instrumentation
Transducers
Ultrasonography instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1560-2281
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of biomedical optics
- Publication Type :
- Academic Journal
- Accession number :
- 25970085
- Full Text :
- https://doi.org/10.1117/1.JBO.20.5.056004