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The relationship between repolarization parameters and serum electrolyte levels in patients with J wave syndromes.
- Source :
-
Magnesium research [Magnes Res] 2015 Jan-Mar; Vol. 28 (1), pp. 1-13. - Publication Year :
- 2015
-
Abstract
- Background: Intravenous administration of magnesium (Mg(2+)) is effective for polymorphic ventricular tachycardia via homogenization of transmural ventricular repolarization. Mg(2+) likely plays some role in the heterogeneity of repolarization in J wave syndromes.<br />Objective: To investigate the relationship between the repolarization parameters and serum Mg(2+), potassium (K(+)), and calcium (Ca(2+)) levels in J wave syndromes.<br />Methods: Thirteen J-wave syndrome patients (Brugada and early repolarization [ER] syndromes), with documented episodes of ventricular fibrillation (VF), and 13 ER pattern (ERP) or Brugada type ECG patients were enrolled (25 males, mean age 48 ± 15 years). The 12-lead ECG-derived parameters including the QT, QT dispersion (QTd), Tpeak-Tend (Tp-e) interval, Tp-e dispersion (Tp-ed), Tp-e/QT ratio, and activation recovery interval (ARI) dispersion were calculated; the correlations between these parameters and electrolytes including Mg(2+), K(+), and Ca(2+) were analyzed.<br />Results: Although there was no association between serum K(+) or Ca(2+) and QTd, there was a strong negative correlation between serum Mg(2+) and QTd in J wave syndrome patients with a history of VF (r = -0.715, p = 0.006). Also, there was a tendency for a negative correlation between Mg(2+) and Tp-ed or ARI dispersion in J wave syndrome patients with a history of VF (r = -0.513, p = 0.072 and r = -0.53, p = 0.063, respectively). On the other hand, in 13 patients with a Brugada type ECG or ERP, no correlation was observed between serum Mg(2+) and the QTd, Tp-ed or ARI dispersion.<br />Conclusion: Serum Mg(2+) may play an important role in the cardiac repolarization process in J wave syndromes.
- Subjects :
- Adult
Brugada Syndrome blood
Brugada Syndrome physiopathology
Calcium blood
Electrocardiography
Female
Humans
Male
Middle Aged
Potassium blood
Syndrome
Ventricular Fibrillation blood
Ventricular Fibrillation physiopathology
Arrhythmias, Cardiac blood
Arrhythmias, Cardiac physiopathology
Electrolytes blood
Magnesium blood
Tachycardia, Ventricular blood
Tachycardia, Ventricular physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1952-4021
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Magnesium research
- Publication Type :
- Academic Journal
- Accession number :
- 25967879
- Full Text :
- https://doi.org/10.1684/mrh.2015.0379