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Global Cognitive Impairment in Systemic Lupus Erythematosus Patients: A Structural MRI Study.
- Source :
-
Clinical neuroradiology [Clin Neuroradiol] 2017 Mar; Vol. 27 (1), pp. 23-29. Date of Electronic Publication: 2015 May 13. - Publication Year :
- 2017
-
Abstract
- Objective: This study investigated differences in subcortical brain volumes of SLE patients with cognitive deficits (SLE-CD) and SLE patients with normal cognitive performance (SLE-CN), regardless of the presence of other neuropsychiatric symptoms.<br />Method: We studied 40 patients divided into two-matched groups (SLE-CD n = 20; SLE-CN n = 20), with age ranging from 21 to 63 years old (100 % female) and 14.73 ± 10.18 years of diagnosis. Magnetic resonance imaging exams were performed on a 1.5 T scanner. A neuropsychological flexible battery was applied individually, including reasoning/problem-solving, praxis, episodic and working memory, processing speed, language/fluency, executive functions (inhibition and flexibility), and sustained attention. Z score ≤ - 2.0 in any dimension was considered as a cut-off for being considered to possess cognitive deficits. One-way analyses of covariance (ANCOVA) were performed to compare the brain structure volumes between groups. The analyses were controlled for the effects of lupus-related neuropsychiatric disorders.<br />Results: SLE patients with cognitive deficits had significantly smaller volumes in the left hippocampus, amygdala, and the right hippocampus than SLE patients without cognitive deficits.<br />Conclusion: SLE patients with cognitive deficits appeared to have reduced temporal lobe structures when compared with SLE without cognitive deficits. These results corroborate a systems vulnerability model that investigated temporal lobe vulnerability during normal aging and in other neurological disorders.
- Subjects :
- Adult
Female
Humans
Male
Middle Aged
Organ Size
Reproducibility of Results
Sensitivity and Specificity
Brain pathology
Cognitive Dysfunction etiology
Cognitive Dysfunction pathology
Lupus Vasculitis, Central Nervous System complications
Lupus Vasculitis, Central Nervous System pathology
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1869-1447
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical neuroradiology
- Publication Type :
- Academic Journal
- Accession number :
- 25967601
- Full Text :
- https://doi.org/10.1007/s00062-015-0397-8