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Targeted Intracellular Controlled Drug Delivery and Tumor Therapy through in Situ Forming Ag Nanogates on Mesoporous Silica Nanocontainers.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2015 Jun 10; Vol. 7 (22), pp. 11930-8. Date of Electronic Publication: 2015 May 29. - Publication Year :
- 2015
-
Abstract
- Targeting nanocontainers to the pathological zone and controlling release of their cargoes, in particular delivery of anticancer drugs to specific tumor cells in a targeted and controlled manner, remain the key challenges in drug delivery. This paper reports the development of a traceable and tumor-targeted intracellular drug release nanocontainer. The nanocontainer is obtained by in situ growth of silver nanoparticles (AgNPs) on the surfaces of mesoporous silica nanospheres (MSNs) using a DNA-templated process. Additionally, drug release from the nanopores is achieved by selective glutathione (GSH)-triggered dismantle of the AgNPs, and the concurrent fluorescence change allows real-time monitoring of drug release efficacy and facile visualization of in vivo delivery events. After being functionalized with sgc8 aptamer on the outer shell of the AgNPs, the targeted nanocontainers are delivered into acute lymphoblastic leukemia cells by aptamer-mediated recognition and endocytosis. Moreover, the GSH-responsive process presents an improvement in the cell-specific drug release and chemotherapeutic inhibition of tumor growth.
- Subjects :
- Aptamers, Nucleotide chemistry
Aptamers, Nucleotide therapeutic use
Doxorubicin administration & dosage
HeLa Cells
Humans
Metal Nanoparticles administration & dosage
Nanospheres therapeutic use
Nanostructures administration & dosage
Porosity
Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
Silicon Dioxide administration & dosage
Silicon Dioxide chemistry
Silver chemistry
Doxorubicin chemistry
Drug Delivery Systems
Metal Nanoparticles chemistry
Nanostructures chemistry
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 7
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 25966745
- Full Text :
- https://doi.org/10.1021/acsami.5b01787