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Carbon-11 radiolabelling of organosulfur compounds: (11) C synthesis of the progesterone receptor agonist tanaproget.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2015 Jun 15; Vol. 21 (25), pp. 9034-8. Date of Electronic Publication: 2015 May 12. - Publication Year :
- 2015
-
Abstract
- Herein a new (11) C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, (11) CS2 , is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [(11) C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with (11) CS2 , which has potential applications as a positron emission tomography radioligand for cancer imaging.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Breast Neoplasms
Humans
Positron-Emission Tomography
Receptors, Progesterone antagonists & inhibitors
Thiourea chemistry
Benzoxazines chemistry
Carbon Radioisotopes chemistry
Parietal Lobe chemistry
Radiopharmaceuticals chemistry
Receptors, Progesterone chemistry
Thiones chemistry
Thiourea chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 21
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 25965348
- Full Text :
- https://doi.org/10.1002/chem.201501089