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Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance.
- Source :
-
Cell metabolism [Cell Metab] 2015 May 05; Vol. 21 (5), pp. 678-91. - Publication Year :
- 2015
-
Abstract
- Obesity, insulin resistance, and related pathologies are associated with immune-mediated chronic inflammation. Kit mutant mice are protected from diet-induced obesity and associated co-morbidities, and this phenotype has previously been attributed to their lack of mast cells. We performed a comprehensive metabolic analysis of Kit-dependent Kit(W/Wv) and Kit-independent Cpa3(Cre/+) mast-cell-deficient mouse strains, employing diet-induced or genetic (Lep(Ob/Ob) background) models of obesity. Our results show that mast cell deficiency, in the absence of Kit mutations, plays no role in the regulation of weight gain or insulin resistance. Moreover, we provide evidence that the metabolic phenotype observed in Kit mutant mice, while independent of mast cells, is immune regulated. Our data underscore the value of definitive mast cell deficiency models to conclusively test the involvement of this enigmatic cell in immune-mediated pathologies and identify Kit as a key hematopoietic factor in the pathogenesis of metabolic syndrome.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Gene Deletion
Hematopoiesis
Male
Mast Cells immunology
Mast Cells metabolism
Metabolic Syndrome genetics
Mice
Mice, Inbred C57BL
Obesity immunology
Obesity pathology
Stem Cell Factor immunology
Transcriptome
Insulin Resistance
Mast Cells pathology
Obesity genetics
Stem Cell Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-7420
- Volume :
- 21
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 25955205
- Full Text :
- https://doi.org/10.1016/j.cmet.2015.04.013