Back to Search
Start Over
A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus.
- Source :
-
The EMBO journal [EMBO J] 2015 Jul 02; Vol. 34 (13), pp. 1786-800. Date of Electronic Publication: 2015 May 07. - Publication Year :
- 2015
-
Abstract
- Coupling cell cycle with nutrient availability is a crucial process for all living cells. But how bacteria control cell division according to metabolic supplies remains poorly understood. Here, we describe a molecular mechanism that coordinates central metabolism with cell division in the α-proteobacterium Caulobacter crescentus. This mechanism involves the NAD-dependent glutamate dehydrogenase GdhZ and the oxidoreductase-like KidO. While enzymatically active GdhZ directly interferes with FtsZ polymerization by stimulating its GTPase activity, KidO bound to NADH destabilizes lateral interactions between FtsZ protofilaments. Both GdhZ and KidO share the same regulatory network to concomitantly stimulate the rapid disassembly of the Z-ring, necessary for the subsequent release of progeny cells. Thus, this mechanism illustrates how proteins initially dedicated to metabolism coordinate cell cycle progression with nutrient availability.<br /> (© 2015 The Authors.)
- Subjects :
- Bacterial Proteins metabolism
Caulobacter crescentus genetics
Cytoskeletal Proteins metabolism
Gene Deletion
Glutamate Dehydrogenase metabolism
NAD metabolism
Organisms, Genetically Modified
Protein Binding
Caulobacter crescentus cytology
Caulobacter crescentus enzymology
Caulobacter crescentus metabolism
Cell Division genetics
Glutamate Dehydrogenase physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2075
- Volume :
- 34
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- The EMBO journal
- Publication Type :
- Academic Journal
- Accession number :
- 25953831
- Full Text :
- https://doi.org/10.15252/embj.201490730