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Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression.
- Source :
-
Nature communications [Nat Commun] 2015 May 08; Vol. 6, pp. 7062. Date of Electronic Publication: 2015 May 08. - Publication Year :
- 2015
-
Abstract
- Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex (mPFC), ventral hippocampus (vHIP) and basolateral amygdala (AMY). Here, we demonstrate that glutamatergic vHIP afferents to NAc regulate susceptibility to chronic social defeat stress (CSDS). We observe reduced activity in vHIP in mice resilient to CSDS. Furthermore, attenuation of vHIP-NAc transmission by optogenetic induction of long-term depression is pro-resilient, whereas acute enhancement of this input is pro-susceptible. This effect is specific to vHIP afferents to the NAc, as optogenetic stimulation of either mPFC or AMY afferents to the NAc is pro-resilient. These data indicate that vHIP afferents to NAc uniquely regulate susceptibility to CSDS, highlighting an important, novel circuit-specific mechanism in depression.
- Subjects :
- Amygdala physiopathology
Animals
Chronic Disease
Disease Susceptibility physiopathology
Gene Expression Regulation
Genes, Immediate-Early
Long-Term Synaptic Depression
Male
Mice, Inbred C57BL
Prefrontal Cortex
Social Behavior
Stress, Psychological physiopathology
Synapses metabolism
Synaptic Transmission
Depression physiopathology
Hippocampus physiopathology
Neurons, Afferent pathology
Nucleus Accumbens physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 25952660
- Full Text :
- https://doi.org/10.1038/ncomms8062