Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST.

Authors :: Keller PM
Hömke R
Ritter C
Valsesia G
Bloemberg GV
Böttger EC
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Jul; Vol. 59 (7), pp. 4352-5. Date of Electronic Publication: 2015 May 04.
Publication Year :: 2015
Abstract: Bedaquiline (Sirturo) and delamanid (Deltyba) have recently been approved by the regulatory authorities for treatment of multidrug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of the use of the MGIT 960 system equipped with EpiCenter/TB eXiST, we determined a mean bedaquiline MIC for wild-type strains of 0.65 mg/liter (median, 0.4 mg/liter) and an epidemiological cutoff (ECOFF) of 1.6 mg/liter; for delamanid, a mean wild-type drug MIC of 0.013 mg/liter (median, 0.01 mg/liter) and an ECOFF of 0.04 mg/liter were determined.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Subjects :: Humans
Reference Values
Tuberculosis drug therapy
Tuberculosis epidemiology
Tuberculosis microbiology
Tuberculosis, Multidrug-Resistant microbiology
Antitubercular Agents pharmacology
Diarylquinolines pharmacology
Microbial Sensitivity Tests
Mycobacterium tuberculosis drug effects
Nitroimidazoles pharmacology
Oxazoles pharmacology

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