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Recovery of Hearing in Meniere's Disease after Antiviral Treatment.
- Source :
-
American journal of otolaryngology [Am J Otolaryngol] 2015 May-Jun; Vol. 36 (3), pp. 315-23. Date of Electronic Publication: 2014 Apr 05. - Publication Year :
- 2015
-
Abstract
- Objective: Determine the outcome of hearing in Meniere's Disease (MD) after antiviral treatment.<br />Study Design: Prospective study.<br />Setting: University Hospital.<br />Methods: Thirty one new patients with a diagnosis of MD were treated with antiviral drugs during 2012. Acyclovir or valacyclovir was used depending on insurance coverage and cost. A standard dose of 800 mg (acyclovir) or 1g (valacyclovir) 3 times a day for 3 weeks was used. The dose was decreased to twice daily for three weeks, and finally once daily for a year or longer. Hearing test including pure tone average (PTA) and speech discrimination (SD) was performed prior to treatment and 1-2 months, 6 months and 1 year after the initiation of treatment. Effect on dizziness was recorded at each evaluation, hearing was judged to be improved if PTA was lowered by at least 15 db and/or an increase in SD of 20% or greater.<br />Results: Hearing was improved in twelve and not improved in nineteen patients. Complete control of vertigo was achieved in those patients with improved hearing. The nineteen patients with no improvement in hearing were divided into 2 groups based on the level of hearing at diagnosis. Nine patients presenting with a PTA of 50 db and SD of 50% or better experienced good control of vertigo (6 out of 7; 2 with no follow-up). Ten patients with PTA of 60 db or more and SD below 50% exhibited poor control of vertigo with antivirals (3 out of 10). The duration of MD in the group with hearing improvement was shorter (2.4 years) than the group with no improvement (5.5 years).<br />Conclusion: Significant hearing and balance control in patients with MD can be achieved with orally administered antiviral drugs.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Audiometry
Female
Hearing Loss, Sensorineural etiology
Hearing Loss, Sensorineural pathology
Humans
Male
Meniere Disease complications
Meniere Disease pathology
Middle Aged
Prospective Studies
Recovery of Function
Treatment Outcome
Valacyclovir
Valine therapeutic use
Vertigo drug therapy
Vertigo etiology
Vertigo pathology
Young Adult
Acyclovir analogs & derivatives
Acyclovir therapeutic use
Antiviral Agents therapeutic use
Hearing Loss, Sensorineural drug therapy
Meniere Disease drug therapy
Valine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1532-818X
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of otolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 25940200
- Full Text :
- https://doi.org/10.1016/j.amjoto.2014.03.016