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Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.
- Source :
-
Brain and language [Brain Lang] 2015 Jun-Jul; Vol. 145-146, pp. 1-10. Date of Electronic Publication: 2015 Apr 29. - Publication Year :
- 2015
-
Abstract
- Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aphasia etiology
Aphasia physiopathology
Brain drug effects
Double-Blind Method
Evoked Potentials drug effects
Female
Functional Laterality drug effects
Functional Laterality physiology
Humans
Male
Memantine pharmacology
Middle Aged
Photic Stimulation methods
Reading
Stroke complications
Stroke physiopathology
Aphasia therapy
Brain physiology
Evoked Potentials physiology
Language Therapy methods
Memantine therapeutic use
Stroke therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2155
- Volume :
- 145-146
- Database :
- MEDLINE
- Journal :
- Brain and language
- Publication Type :
- Academic Journal
- Accession number :
- 25932618
- Full Text :
- https://doi.org/10.1016/j.bandl.2015.04.003