Mir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer.

Authors :: Shi L
Zhang C
Zhao D
Liu K
Li T
Tian H
Source :: International journal of clinical and experimental medicine [Int J Clin Exp Med] 2015 Feb 15; Vol. 8 (2), pp. 2600-6. Date of Electronic Publication: 2015 Feb 15 (Print Publication: 2015).
Publication Year :: 2015
Abstract: Objective: This study aimed to gain a better insight into the impact of the mir-196a-2 C>T polymorphism on the susceptibility to colorectal cancer (CRC).<br />Methods: In a meta-analysis of 6 publications with a total of 1,754 cancer cases and 2,430 controls, we summarized the data on the associations between the studied mir-196a-2 C>T polymorphism and CRC risk and conducted subgroup analyses by ethnicity and control sources.<br />Results: We found no overall association between the mir-196a-2 C>T polymorphism and CRC risk. But a significant association was found in the stratified analysis according to ethnicity among Asians (ORCC vs. TT = 1.22, 95% CI = 1.02-1.45, P heterogeneity = 0.718; ORCC vs. TC + TT = 1.22, 95% CI = 1.04-1.44, P heterogeneity = 0.590; ORallele C vs. allele T = 1.10, 95% CI = 1.01-1.20, P heterogeneity = 0.726) rather than Caucasians.<br />Conclusions: Our results suggested that there was no overall risk of CRC in relation to the mir-196a-2 C>T polymorphism. However, this polymorphism was associated with an increased risk in Asian populations.

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