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Anti-M Antibody Induced Prolonged Anemia Following Hemolytic Disease of the Newborn Due to Erythropoietic Suppression in 2 Siblings.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2015 Aug; Vol. 37 (6), pp. e375-7. - Publication Year :
- 2015
-
Abstract
- Hemolytic disease of the newborn (HDN) arising from MNSs incompatibility is rare, with few reports of prolonged anemia and reticulocytopenia following HDN. We report the younger of 2 male siblings, both of whom had anti-M-induced HDN and anemia persisting for over a month. Peripheral reticulocytes remained inappropriately low for the degree of anemia, and they needed multiple red cell transfusions. Viral infections were ruled out. Corticosteroids were given for suspected pure red cell aplasia. Anemia and reticulocytopenia subsequently improved. Colony-forming unit erythroid assay revealed erythropoietic suppression of M antigen-positive erythroid precursor cells cultured with maternal or infant sera containing anti-M. In conclusion, maternal anti-M caused HDN and prolonged anemia by erythropoietic suppression in 2 siblings.
- Subjects :
- Adult
Anemia pathology
Cell Differentiation
Colony-Forming Units Assay
Erythroblastosis, Fetal pathology
Erythroid Precursor Cells immunology
Female
Humans
Immunoglobulin M blood
Infant
Infant, Newborn
Male
Pregnancy
Prognosis
Siblings
Anemia etiology
Erythroblastosis, Fetal etiology
Erythroid Precursor Cells pathology
Erythropoiesis immunology
Immunoglobulin M immunology
Isoantibodies immunology
Red-Cell Aplasia, Pure complications
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25929611
- Full Text :
- https://doi.org/10.1097/MPH.0000000000000341