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The efficacy of radio-frequency ablation for metastatic lung or liver tumors of male germ cell tumors as an alternative minimally invasive therapy after salvage chemotherapy.

Authors :
Naya Y
Nakamura T
Oishi M
Ueda T
Nakanishi H
Naitoh Y
Hongo F
Kamoi K
Okihara K
Tanaka O
Yamagami T
Yamada K
Miki T
Source :
International journal of clinical oncology [Int J Clin Oncol] 2015 Dec; Vol. 20 (6), pp. 1192-7. Date of Electronic Publication: 2015 Apr 30.
Publication Year :
2015

Abstract

Background: The aim of this study was to assess the efficacy of radio-frequency ablation (RFA) for metastatic lung or liver tumors of germ cell tumors (GCTs) after chemotherapy.<br />Methods: RFA with computed tomography guidance and monitoring was performed in 24 patients with 48 metastatic lung or liver tumors of GCTs. Group A consisted of 9 patients with tumor marker normalization after salvage chemotherapy and group B consisted of 15 patients without tumor marker normalization in spite ofintensive treatment.<br />Results: Out of 48 tumors, 41 tumors in 21 patients were evaluated for the efficacy of the RFA treatment. Of the 41 tumors, successful ablation was achieved in 34 (82.9 %). The patients in group A had significantly better survival than the patients in group B (p = 0.0003). In group A, all 9 patients are still alive with no evidence of disease (NED). Patients with a solitary tumor had significantly better survival than those with multiple tumors (p = 0.0247). In group B, 2 patients are alive with NED, 1 patient is alive with disease, and the remaining 12 patients have died a tumor-related death. Three cases of pneumothorax requiring intubation were observed.<br />Conclusions: RFA is less invasive than surgery and is an effective treatment option for curative and palliative therapy as an alternative to invasive salvage surgery for post-chemotherapeutic metastatic lung or liver lesions from GCT.

Details

Language :
English
ISSN :
1437-7772
Volume :
20
Issue :
6
Database :
MEDLINE
Journal :
International journal of clinical oncology
Publication Type :
Academic Journal
Accession number :
25924698
Full Text :
https://doi.org/10.1007/s10147-015-0824-5