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Lower 1,5-anhydroglucitol is associated with adverse clinical events after percutaneous coronary intervention.
- Source :
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Heart and vessels [Heart Vessels] 2016 Jun; Vol. 31 (6), pp. 855-62. Date of Electronic Publication: 2015 Apr 29. - Publication Year :
- 2016
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Abstract
- Diabetes mellitus and impaired glucose tolerance are well-known risk factors for coronary artery disease (CAD) and adverse clinical events after percutaneous coronary intervention (PCI). Postprandial hyperglycemia is an important risk factor for CAD and serum 1,5-anhydroglucitol (1,5-AG) reflects postprandial hyperglycemia more robustly than hemoglobin (Hb)A1c. We aimed to clarify the relationship between serum 1,5-AG level and adverse clinical events after PCI. We enrolled 141 patients after PCI with follow-up coronary angiography. We evaluated associations between glycemic biomarkers including HbA1c and 1,5-AG and cardiovascular events during follow-up. Median serum 1,5-AG level was significantly lower in patients with any coronary revascularization and target lesion revascularization (TLR) [13.4 µg/ml (first quartile, third quartile 9.80, 18.3) vs. 18.7 (12.8, 24.2), p = 0.005; 13.4 µg/ml (10.2, 16.4) vs. 18.7 (12.9, 24.2), p = 0.001, respectively]. Multivariate logistic analysis showed lower 1,5-AG was independently associated with any coronary revascularization and TLR (odds ratio 0.93, 95 % confidence interval 0.86-0.99, p = 0.04; 0.90, 0.81-0.99, p = 0.044, respectively), whereas higher HbA1c was not. Postprandial hyperglycemia and lower 1,5-AG are important risk factors for adverse clinical events after PCI.
- Subjects :
- Aged
Biomarkers blood
Blood Glucose metabolism
Chi-Square Distribution
Coronary Angiography
Diabetes Mellitus diagnosis
Down-Regulation
Female
Glycated Hemoglobin metabolism
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction blood
Myocardial Infarction diagnostic imaging
Odds Ratio
Prospective Studies
Risk Factors
Time Factors
Treatment Outcome
Deoxyglucose blood
Diabetes Mellitus blood
Myocardial Infarction therapy
Percutaneous Coronary Intervention adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1615-2573
- Volume :
- 31
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Heart and vessels
- Publication Type :
- Academic Journal
- Accession number :
- 25921916
- Full Text :
- https://doi.org/10.1007/s00380-015-0682-0