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P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study.
- Source :
-
Heart rhythm [Heart Rhythm] 2015 Sep; Vol. 12 (9), pp. 1887-95. Date of Electronic Publication: 2015 Apr 23. - Publication Year :
- 2015
-
Abstract
- Background: Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.<br />Objective: The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.<br />Methods: Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.<br />Results: A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100-105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.41-1.81), intermediate (112-119 ms; HR 1.22, 95% CI 1.13-1.31), long (120-129 ms; HR 1.50, 95% CI 1.39-1.62), and very long P-wave duration (≥130 ms; HR 2.06, 95% CI 1.89-2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (≤89 ms; HR 1.20, 95% CI 1.06-1.34), long (120-129 ms; HR 1.11, 95% CI 1.04-1.19), and very long P-wave duration (≥130 ms; HR 1.30, 95% CI 1.21-1.40) compared with the reference group (106-111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke.<br />Conclusion: In a large primary care population we found both short and long P-wave duration to be robustly associated with an increased risk of AF.<br /> (Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Atrial Fibrillation complications
Atrial Fibrillation epidemiology
Brain Ischemia diagnosis
Brain Ischemia epidemiology
Brain Ischemia etiology
Denmark epidemiology
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Risk Assessment methods
Risk Factors
Survival Rate trends
Time Factors
Tomography, X-Ray Computed
Atrial Fibrillation physiopathology
Electrocardiography methods
Registries
Subjects
Details
- Language :
- English
- ISSN :
- 1556-3871
- Volume :
- 12
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Heart rhythm
- Publication Type :
- Academic Journal
- Accession number :
- 25916567
- Full Text :
- https://doi.org/10.1016/j.hrthm.2015.04.026