Back to Search
Start Over
Practical prognostic index for survival in patients with unresectable pancreatic cancer treated with gemcitabine or S-1.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2015 Mar-Apr; Vol. 62 (138), pp. 478-84. - Publication Year :
- 2015
-
Abstract
- Background/aims: We performed this retrospective cohort study to identify prognostic factors for unresectable pancreatic cancer treated with current standard therapy using gemcitabine (GEM) or S-1 and to stratify patients prior to treatment using a prognostic index (PI).<br />Methodology: We analyzed 182 patients with unresectable pancreatic cancer, who had received GEM or S-1 as first-line chemotherapy. Factors that contributed to the prognosis were identified by univariate and multivariate analysis using a Cox proportional hazards model. The PI was constructed using the factors identified in the multivariate analysis.<br />Results: By multivariate analysis, performance status (PS), stage, and absolute neutrophil count (ANC) were identified as factors that independently contributed to the prognosis of unresectable pancreatic cancer (P < 0.05). The hazard ratios were 1.69, 3.33, and 1.18, respectively. In addition, PI was calculated using these three factors. Patients were classified into three groups according to the PI values. A significant difference was observed among the survival curves of these three groups (P < 0.05).<br />Conclusions: We identified three prognostic factors in the population after the introduction of S-1, and have created a simple and useful PI. This index demonstrates the ability to accurately classify advanced pancreatic cancer patients before the start of treatment.
- Subjects :
- Adult
Aged
Aged, 80 and over
Deoxycytidine therapeutic use
Drug Combinations
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Neutrophils pathology
Pancreatic Neoplasms classification
Pancreatic Neoplasms mortality
Pancreatic Neoplasms pathology
Patient Selection
Proportional Hazards Models
Retrospective Studies
Time Factors
Treatment Outcome
Gemcitabine
Antimetabolites, Antineoplastic therapeutic use
Decision Support Techniques
Deoxycytidine analogs & derivatives
Oxonic Acid therapeutic use
Pancreatic Neoplasms drug therapy
Tegafur therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 62
- Issue :
- 138
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25916086