Back to Search
Start Over
New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression.
- Source :
-
Organic letters [Org Lett] 2015 May 15; Vol. 17 (10), pp. 2330-3. Date of Electronic Publication: 2015 Apr 27. - Publication Year :
- 2015
-
Abstract
- Two novel meroterpenoids, yaminterritrems A (1) and B (2), were isolated from Aspergillus terreus collected from hot spring zones in Yang-Ming Mountain, Taiwan, and cultured at 40 °C. The structures of 1 and 2 were elucidated by NMR, MS spectral and X-ray crystallographic analyses. The biosynthetic route for 1 and 2 involving the conversion of the sesquiterpene with phenyl-α-pyrone is proposed. Besides, 2 exhibited a dose-dependent inhibitory effect on COX-2 expression in LPS-stimulated RAW264.7 macrophages.
- Subjects :
- Crystallography, X-Ray
Lipopolysaccharides pharmacology
Macrophages drug effects
Magnetic Resonance Spectroscopy
Molecular Structure
Taiwan
Aspergillus chemistry
Cyclooxygenase 2 Inhibitors chemistry
Cyclooxygenase 2 Inhibitors metabolism
Pyrones chemistry
Sesquiterpenes chemistry
Sesterterpenes biosynthesis
Sesterterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 17
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 25915447
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b00739