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Synthesis and antibacterial activities of cadiolides A, B and C and analogues.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Jul 01; Vol. 23 (13), pp. 3618-28. Date of Electronic Publication: 2015 Apr 10. - Publication Year :
- 2015
-
Abstract
- The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- 4-Butyrolactone chemical synthesis
4-Butyrolactone pharmacology
Anti-Bacterial Agents pharmacology
Cell Survival drug effects
Gram-Negative Bacteria drug effects
Gram-Negative Bacteria growth & development
Gram-Positive Bacteria drug effects
Gram-Positive Bacteria growth & development
Humans
Microbial Sensitivity Tests
Molecular Structure
Neutrophils cytology
Neutrophils drug effects
Primary Cell Culture
Structure-Activity Relationship
4-Butyrolactone analogs & derivatives
Anti-Bacterial Agents chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 23
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25913865
- Full Text :
- https://doi.org/10.1016/j.bmc.2015.04.010