DNA and RNA derivatives to optimize distribution and delivery.

Authors :: Wickstrom E
Source :: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2015 Jun 29; Vol. 87, pp. 25-34. Date of Electronic Publication: 2015 Apr 22.
Publication Year :: 2015
Abstract: Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and RNAs, however, are readily digested in biological systems. Hence, chemists are obliged to design and synthesize nuclease-resistant analogs of normal DNA (Fig. 1).<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)