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Genetic characterization of Chikungunya virus in the Central African Republic.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2015 Jul; Vol. 33, pp. 25-31. Date of Electronic Publication: 2015 Apr 22. - Publication Year :
- 2015
-
Abstract
- Chikungunya virus (CHIKV) is an alphavirus transmitted by the bite of mosquito vectors. Over the past 10 years, the virus has gained mutations that enhance its transmissibility by the Aedes albopictus vector, resulting in massive outbreaks in the Indian Ocean, Asia and Central Africa. Recent introduction of competent A. albopictus vectors into the Central African Republic (CAR) pose a threat of a Chikungunya fever (CHIKF) epidemic in this region. We undertook this study to assess the genetic diversity and background of CHIKV strains isolated in the CAR between 1975 and 1984 and also to estimate the ability of local strains to adapt to A. albopictus. Our results suggest that, local CHIKV strains have a genetic background compatible with quick adaptation to A. albopictus, as previously observed in other Central African countries. Intense surveillance of the human and vector populations is necessary to prevent or anticipate the emergence of a massive CHIKF epidemic in the CAR.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Central African Republic epidemiology
Chikungunya Fever transmission
Chikungunya virus classification
Chikungunya virus isolation & purification
Geography
Humans
Insect Vectors
Phylogeny
Population Surveillance
Sequence Analysis, DNA
Viral Proteins genetics
Chikungunya Fever epidemiology
Chikungunya Fever virology
Chikungunya virus genetics
Genetic Variation
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 33
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 25911440
- Full Text :
- https://doi.org/10.1016/j.meegid.2015.04.006