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Prevention of postmenopausal bone loss in rheumatoid arthritis patients. A two-year prospective study.
- Source :
-
Clinical and experimental rheumatology [Clin Exp Rheumatol] 1989 Jul-Aug; Vol. 7 (4), pp. 351-8. - Publication Year :
- 1989
-
Abstract
- The effect of three different therapeutic regimens on bone mineral content at the radius and lumbar spine was studied in a group of 60 postmenopausal rheumatoid arthritis patients. Results were compared to those in a group of controls matched for sex, age, disease duration and menopausal state. Serum and urinary parameters of calcium metabolism were also evaluated in the three treatment groups. The three treatment regimens were: 1 alpha hydroxyvitamin D + calcium + placebo; 1 alpha hydroxyvitamin D + calcium + lynestrenol; and 1 alpha hydroxyvitamin D + calcium + sodium fluoride. In all treatment groups there was a positive effect of therapy compared to controls, though this was only significant in the 1 alpha hydroxyvitamin D + calcium + lynestrenol group at the axial skeleton after 1 and 2 years of treatment. Serum calcium rose significantly in the 1 alpha hydroxyvitamin D + calcium + placebo group and serum creatinin was raised in all the treatment groups during therapy. In the 1 alpha hydroxyvitamin D + calcium + lynestrenol group, serum alkaline phosphatase activity and urinary hydroxyproline excretion decreased significantly.
- Subjects :
- Aged
Arthritis, Rheumatoid metabolism
Calcium blood
Calcium metabolism
Calcium therapeutic use
Calcium urine
Drug Therapy, Combination
Female
Humans
Hydroxycholecalciferols therapeutic use
Lynestrenol therapeutic use
Middle Aged
Prospective Studies
Random Allocation
Sodium Fluoride therapeutic use
Time Factors
Arthritis, Rheumatoid complications
Bone Density drug effects
Osteoporosis, Postmenopausal prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0392-856X
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical and experimental rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 2591109