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A comparative MRI study of cartilage damage in gout versus rheumatoid arthritis.
- Source :
-
Journal of medical imaging and radiation oncology [J Med Imaging Radiat Oncol] 2015 Aug; Vol. 59 (4), pp. 431-435. Date of Electronic Publication: 2015 Apr 23. - Publication Year :
- 2015
-
Abstract
- Introduction: Magnetic resonance imaging (MRI) is useful for detecting joint inflammation and damage in the inflammatory arthropathies. This study aimed to investigate MRI cartilage damage and its associations with joint inflammation in patients with gout compared with a group with rheumatoid arthritis (RA).<br />Methods: Forty patients with gout and 38 with seropositive RA underwent 3T-MRI of the wrist with assessment of cartilage damage at six carpal sites, using established scoring systems. Synovitis and bone oedema (BME) were graded according to Rheumatoid Arthritis MRI Scoring System criteria. Cartilage damage was compared between the groups adjusting for synovitis and disease duration using logistic regression analysis.<br />Results: Compared with RA, there were fewer sites of cartilage damage and lower total damage scores in the gout group (P = 0.02 and 0.003), adjusting for their longer disease duration and lesser degree of synovitis. Cartilage damage was strongly associated with synovitis in both conditions (R = 0.59, P < 0.0001 and R = 0.52, P = 0.0045 respectively) and highly correlated with BME in RA (R = 0.69, P < 0.0001) but not in gout (R = 0.095, P = 0.56).<br />Conclusions: Cartilage damage is less severe in gout than in RA, with fewer sites affected and lower overall scores. It is associated with synovitis in both diseases, likely indicating an effect of pro-inflammatory cytokine production on cartilage integrity. However, the strong association between cartilage damage and BME observed in RA was not identified in gout. This emphasizes differences in the underlying pathophysiology of joint damage in these two conditions.<br /> (© 2015 The Royal Australian and New Zealand College of Radiologists.)
- Subjects :
- Adult
Aged
Arthritis, Rheumatoid complications
Cartilage Diseases etiology
Female
Gout complications
Humans
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Arthritis, Rheumatoid pathology
Cartilage pathology
Cartilage Diseases pathology
Gout pathology
Magnetic Resonance Imaging methods
Wrist Joint pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1754-9485
- Volume :
- 59
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of medical imaging and radiation oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25908527
- Full Text :
- https://doi.org/10.1111/1754-9485.12306