Back to Search
Start Over
Cerebrospinal Fluid Monoamine Metabolite Analysis in Pediatric Movement Disorders.
- Source :
-
Journal of child neurology [J Child Neurol] 2015 Nov; Vol. 30 (13), pp. 1800-5. Date of Electronic Publication: 2015 Apr 23. - Publication Year :
- 2015
-
Abstract
- Abnormal concentrations of dopamine and serotonin metabolites in the cerebrospinal fluid is the diagnostic hallmark of a group of treatable conditions known as the monoamine neurotransmitter disorders. We assessed cerebrospinal fluid dopamine and serotonin metabolite concentrations in a series of 69 patients affected by movement disorders of unknown etiology. Abnormal results were disclosed in 13/69 subjects (19%). Both primary and secondary monoamine neurotransmitter disorders were observed. The clinical presentation of both forms was hypokinetic-rigid syndrome or dystonia. L-Dopa treatment resulted in significant improvement of the clinical picture in the majority of primary neurotransmitter disorders. Eight patients presented a secondary neurotransmitter disorder. One suffered from a GM2 gangliosidosis and one from infantile bilateral striatal necrosis. Etiologic diagnoses were not established in the others. L-Dopa was started in four patients, leading to a significant improvement of hypokinesia in the patient suffering from GM2 gangliosidosis and a slight improvement in 3 unclassified patients.<br /> (© The Author(s) 2015.)
Details
- Language :
- English
- ISSN :
- 1708-8283
- Volume :
- 30
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Journal of child neurology
- Publication Type :
- Academic Journal
- Accession number :
- 25907776
- Full Text :
- https://doi.org/10.1177/0883073815581608