Influence of key amino acid mutation on the active site structure and on folding in acetyl-CoA synthase: a theoretical perspective.

Authors :: Greco C
Ciancetta A
Bruschi M
Kulesza A
Moro G
Cosentino U
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2015 May 18; Vol. 51 (40), pp. 8551-4.
Publication Year :: 2015
Abstract: Ad hoc quantum chemical modeling of the acetyl-CoA synthase local structure and folding allowed us to identify an unprecedented coordination mode of histidine sidechain to protein-embedded metal ions.

Subjects :: Catalytic Domain
Mutation
Protein Folding
Acetate-CoA Ligase chemistry
Aldehyde Oxidoreductases chemistry
Cysteine chemistry
Histidine chemistry
Models, Molecular
Multienzyme Complexes chemistry

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