Back to Search
Start Over
VEGFR-1 overexpression identifies a small subgroup of aggressive prostate cancers in patients treated by prostatectomy.
VEGFR-1 overexpression identifies a small subgroup of aggressive prostate cancers in patients treated by prostatectomy.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2015 Apr 16; Vol. 16 (4), pp. 8591-606. Date of Electronic Publication: 2015 Apr 16. - Publication Year :
- 2015
-
Abstract
- The VEGFR-1 is suggested to promote tumor progression. In the current study we analyzed prevalence and prognostic impact of the VEGFR-1 by immunohistochemistry on a tissue microarray containing more than 3000 prostate cancer specimens. Results were compared to tumor phenotype, ETS-related gene (ERG) status, and biochemical recurrence. Membranous VEGFR-1 expression was detectable in 32.6% of 2669 interpretable cancers and considered strong in 1.7%, moderate in 6.7% and weak in 24.2% of cases. Strong VEGFR-1 expression was associated with TMPRSS2:ERG fusion status as determined by fluorescence in situ hybridization (FISH) and immunohistochemistry (p < 0.0001 each). Elevated VEGFR-1 expression was linked to high Gleason grade and advanced pT stage in TMPRSS2:ERG negative cancers (p = 0.0008 and p = 0.001), while these associations were absent in TMPRSS2:ERG positive cancers. VEGFR-1 expression was also linked to phosphatase and tensin homolog (PTEN) deletions. A comparison with prostate specific antigen (PSA) recurrence revealed that the 1.7% of prostate cancers with the highest VEGFR-1 levels had a strikingly unfavorable prognosis. This could be seen in all cancers, in the subsets of TMPRSS2:ERG positive or negative, PTEN deleted or undeleted carcinomas (p < 0.0001 each). High level VEGFR-1 expression is infrequent in prostate cancer, but identifies a subgroup of aggressive cancers, which may be candidates for anti-VEGFR-1 targeted therapy.
- Subjects :
- Aged
Biomarkers, Tumor genetics
Disease-Free Survival
Gene Expression
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local prevention & control
Prognosis
Prostatectomy
Prostatic Neoplasms pathology
Prostatic Neoplasms surgery
Vascular Endothelial Growth Factor Receptor-1 genetics
Biomarkers, Tumor metabolism
Neoplasm Recurrence, Local metabolism
Prostatic Neoplasms metabolism
Vascular Endothelial Growth Factor Receptor-1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25894226
- Full Text :
- https://doi.org/10.3390/ijms16048591