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No effect of risedronate on femoral periprosthetic bone loss following total hip arthroplasty. A 4-year follow-up of 61 patients in a double-blind, randomized placebo-controlled trial.
- Source :
-
Acta orthopaedica [Acta Orthop] 2015; Vol. 86 (5), pp. 569-74. - Publication Year :
- 2015
-
Abstract
- Background and Purpose: We have previously shown that during the first 2 years after total hip arthroplasty (THA), periprosthetic bone resorption can be prevented by 6 months of risedronate therapy. This follow-up study investigated this effect at 4 years.<br />Patients and Methods: A single-center, double-blind, randomized placebo-controlled trial was carried out from 2006 to 2010 in 73 patients with osteoarthritis of the hip who were scheduled to undergo THA. The patients were randomly assigned to receive either 35 mg risedronate or placebo orally, once a week, for 6 months postoperatively. The primary outcome was the percentage change in bone mineral density (BMD) in Gruen zones 1 and 7 in the proximal part of the femur at follow-up. Secondary outcomes included migration of the femoral stem and clinical outcome scores.<br />Results: 61 of the 73 patients participated in this 4-year (3.9- to 4.1-year) follow-up study. BMD was similar in the risedronate group (n = 30) and the placebo group (n = 31). The mean difference was -1.8% in zone 1 and 0.5% in zone 7. Migration of the femoral stem, the clinical outcome, and the frequency of adverse events were similar in the 2 groups.<br />Interpretation: Although risedronate prevents periprosthetic bone loss postoperatively, a decrease in periprosthetic BMD accelerates when therapy is discontinued, and no effect is seen at 4 years. We do not recommend the use of risedronate following THA for osteoarthritis of the hip.
- Subjects :
- Absorptiometry, Photon
Adult
Aged
Arthroplasty, Replacement, Hip adverse effects
Double-Blind Method
Female
Follow-Up Studies
Humans
Male
Middle Aged
Postoperative Complications prevention & control
Treatment Outcome
Bone Density drug effects
Bone Density Conservation Agents therapeutic use
Bone Remodeling drug effects
Bone Resorption prevention & control
Osteoarthritis, Hip surgery
Risedronic Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1745-3682
- Volume :
- 86
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta orthopaedica
- Publication Type :
- Academic Journal
- Accession number :
- 25885280
- Full Text :
- https://doi.org/10.3109/17453674.2015.1041846