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The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia.
- Source :
-
Bipolar disorders [Bipolar Disord] 2015 Aug; Vol. 17 (5), pp. 528-35. Date of Electronic Publication: 2015 Apr 15. - Publication Year :
- 2015
-
Abstract
- Objectives: We tested the hypothesis that a common functional variant in brain-derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia (SCZ) and schizoaffective disorder (SAD), is also associated with antipsychotic-induced weight gain in bipolar disorder (BPD). Association of Val66Met with other metabolic measures, including high- and low-density cholesterol, triglycerides, total cholesterol, fasting blood glucose, and hemoglobin A1c, was also tested.<br />Methods: This was a 12-month, prospective, randomized trial of two atypical antipsychotic drugs (APDs) with moderate (risperidone) or high (olanzapine) risk to cause weight gain. Subjects were diagnosed as having BPD (n = 90) and SCZ or SAD (n = 76).<br />Results: BMI was significantly greater in all diagnoses for Met66 allele carriers at six months (p = 0.01). Met66 carriers with BPD showed a greater increase in the triglycerides/high-density (HDL) cholesterol ratio (p = 0.01), a key marker for metabolic syndrome related to insulin resistance, and log-triglycerides (p = 0.04), after three or six months of treatment. Met66 carriers had the greatest increase in log-triglycerides (p = 0.03) and triglycerides/HDL cholesterol ratio after three months of treatment with risperidone (p = 0.003), and the highest BMI at six months (p = 0.01).<br />Conclusions: The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Alleles
Benzodiazepines adverse effects
Blood Glucose metabolism
Body Mass Index
Cholesterol, HDL metabolism
Cholesterol, LDL metabolism
Dyslipidemias chemically induced
Dyslipidemias genetics
Dyslipidemias metabolism
Female
Genotype
Glycated Hemoglobin metabolism
Humans
Male
Middle Aged
Obesity chemically induced
Obesity metabolism
Olanzapine
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Prospective Studies
Risk Factors
Risperidone adverse effects
Triglycerides metabolism
Antipsychotic Agents adverse effects
Bipolar Disorder drug therapy
Brain-Derived Neurotrophic Factor genetics
Insulin Resistance genetics
Obesity genetics
Psychotic Disorders drug therapy
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1399-5618
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bipolar disorders
- Publication Type :
- Academic Journal
- Accession number :
- 25874530
- Full Text :
- https://doi.org/10.1111/bdi.12294