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Role of IL-38 and its related cytokines in inflammation.
- Source :
-
Mediators of inflammation [Mediators Inflamm] 2015; Vol. 2015, pp. 807976. Date of Electronic Publication: 2015 Mar 19. - Publication Year :
- 2015
-
Abstract
- Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.
Details
- Language :
- English
- ISSN :
- 1466-1861
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- Mediators of inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 25873772
- Full Text :
- https://doi.org/10.1155/2015/807976