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FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling.
- Source :
-
Cancer cell [Cancer Cell] 2015 Apr 13; Vol. 27 (4), pp. 429-31. - Publication Year :
- 2015
-
Abstract
- Perhaps the most pressing need in cancer therapeutics is to understand drug resistance. In this issue of Cancer Cell, Hirata and colleagues show that melanoma-associated fibroblasts can drive resistance to the BRAF inhibitor PLX4720 by stimulating matrix production/remodeling, and, consequently, survival signaling in melanoma cells via β1-integrin, Src, and FAK.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 25873166
- Full Text :
- https://doi.org/10.1016/j.ccell.2015.03.013