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Naturally occurring reassortant infectious bursal disease virus in northern China.
- Source :
-
Virus research [Virus Res] 2015 May 04; Vol. 203, pp. 92-5. Date of Electronic Publication: 2015 Apr 11. - Publication Year :
- 2015
-
Abstract
- Infectious bursal disease virus (IBDV) is a bi-segmented, double-stranded RNA virus that belongs to the genus Avibirnavirus of the family of Birnavirideae. The co-evolution of genome segments is a major evolutionary feature for IBDV. However, in recent years, some strains exhibited markedly different genetic relationships for segments A and B. In this study, we firstly isolated a new type of reassortment IBDV strain named IBD13HeB01 from northern China. The full-length genomes of segments A and B were cloned and identified. Sequence analysis revealed that IBD13HeB01 was a segment-reassortment strain, whose segment A was derived from very virulent strain and segment B from attenuated IBDV. In addition, the virulence of IBD13HeB01 strain was evaluated using SPF chickens. This study is not only beneficial for further understanding of the viral evolution but also suggests the potential risk of application of the live vaccines of IBDV.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Birnaviridae Infections virology
Chickens
China
Cluster Analysis
Genome, Viral
Infectious bursal disease virus pathogenicity
Molecular Sequence Data
Phylogeny
RNA, Viral genetics
Reassortant Viruses pathogenicity
Sequence Analysis, DNA
Sequence Homology
Virulence
Birnaviridae Infections veterinary
Infectious bursal disease virus genetics
Infectious bursal disease virus isolation & purification
Poultry Diseases virology
Reassortant Viruses genetics
Reassortant Viruses isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7492
- Volume :
- 203
- Database :
- MEDLINE
- Journal :
- Virus research
- Publication Type :
- Academic Journal
- Accession number :
- 25869881
- Full Text :
- https://doi.org/10.1016/j.virusres.2015.04.003