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HIV-1 prevalence and subtype/recombinant distribution among travelers entering China from Vietnam at the HeKou port in the Yunnan province, China, between 2003 and 2012.
- Source :
-
Journal of medical virology [J Med Virol] 2015 Sep; Vol. 87 (9), pp. 1500-9. Date of Electronic Publication: 2015 Apr 10. - Publication Year :
- 2015
-
Abstract
- The aim of this study was to assess HIV-1 prevalence and the distribution of HIV-1 subtypes among travelers crossing the border at the HeKou land port. Between 2003 and 2012, 22,799 persons were randomly recruited from people entering China from Vietnam. In this crossing border population, a total of 161 (0.71%) travelers were determined as HIV-1-positive. From them, 140 HIV-1-positive serum samples were collected for RNA extraction and subsequent RT-nested PCR amplification of the group-specific antigen (gag)-RT with a length of 2.6 kb. The DNA sequences were analyzed to determine the HIV-1 subtypes/recombinants. We found that the circulating recombinant form 01&#95;AE (CRF01&#95;AE) was the most common HIV-1 subtype, accounting for 49.4% (41/83) of the subtyped 83 samples, followed by CRF08&#95;BC (26.5%, 22/83) and CRF07&#95;BC (7.2%, 6/83). Only 1 sample was classified as subtype C. Thirteen cases could not be clustered into any known subtypes or CRFs and presented as unique recombinant forms (URFs). Of them, 6 recombination patterns were identified. They had distinct structures consisting of fragments of subtypes B, C, CRF01&#95;AE, CRF07&#95;BC and CRF08&#95;BC. Between 2003 and 2012, CRF01&#95;AE and CRE08&#95;BC were shown to be the most prevalent recombinant forms identified each year. But yearly change of each subtype is uncertain regular among in these travelers during the past decade. Understanding the distribution of HIV-1 subtypes/recombinants and how it changes across time among individuals entering China from Vietnam through this land port is crucial to establish strategies for the prevention of HIV cross-border transmission.<br /> (© 2015 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Base Sequence
China epidemiology
Cross-Sectional Studies
Female
Genotype
HIV Infections ethnology
HIV Infections prevention & control
HIV-1 genetics
HIV-1 isolation & purification
Humans
Male
Middle Aged
Molecular Epidemiology
Phylogeny
Polymerase Chain Reaction
Prevalence
Time Factors
Vietnam ethnology
Young Adult
HIV Infections epidemiology
HIV Infections virology
HIV-1 classification
Travel
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9071
- Volume :
- 87
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of medical virology
- Publication Type :
- Academic Journal
- Accession number :
- 25865741
- Full Text :
- https://doi.org/10.1002/jmv.24202