[Detection of chromosomal aneuploidies in spontaneous abortion samples by fluorescence in situ hybridization].

Authors :: Wei P
Li Y
Chen C
Zeng L
Qin S
Wang X
Xi N
Source :: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2015 Apr; Vol. 32 (2), pp. 229-32.
Publication Year :: 2015
Abstract: Objective: To analyze 81 spontaneous abortion samples with fluorescence in situ hybridization (FISH).<br />Methods: Chromosome 13, 21, 16, 22, 18, X and Y probes were used to detect the samples.<br />Results: FISH was successful in 80 cases (98.77%). Among these, 35 (43.75%) had an abnormal karyotype, which included 19 autosomal aneuploidies, 6 sex chromosome aneuploidies, 9 triploidies and 1 tetraploidy.<br />Conclusion: FISH is a rapid and easy method for detecting chromosomal aneuploidies in spontaneous abortion samples, and has a higher detection rate in early spontaneous abortion samples.

Subjects :: Abortion, Spontaneous diagnosis
Adult
Chromosome Aberrations
Female
Fetal Diseases diagnosis
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Pregnancy
Prenatal Diagnosis
Young Adult
Abortion, Spontaneous genetics
Aneuploidy
Chromosomes, Mammalian genetics
Fetal Diseases genetics

Language :: Chinese
ISSN :: 1003-9406
Volume :: 32
Issue :: 2
Database :: MEDLINE
Journal :: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Publication Type :: Academic Journal
Accession number :: 25863093
Full Text :: https://doi.org/10.3760/cma.j.issn.1003-9406.2015.02.017

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