Back to Search
Start Over
Effect of ethnicity on first trimester biomarkers for combined trisomy 21 screening: results from a multicenter study in six Asian countries.
- Source :
-
Prenatal diagnosis [Prenat Diagn] 2015 Aug; Vol. 35 (8), pp. 735-40. Date of Electronic Publication: 2015 May 27. - Publication Year :
- 2015
-
Abstract
- Objective: To assess differences between first trimester trisomy 21 screening markers free beta chain of the human chorionic gonadotrophin (βhCG) and pregnancy-associated plasma protein A (PAPP-A) in pregnant women of six different Asian countries (China, Indonesia, Korea, Taiwan, Thailand, and Vietnam) and compare serum levels with those in women of European countries.<br />Methods: Median and multiple of median (MoM) values of free βhCG and PAPP-A were determined in more than 3000 pregnant women from the Asian countries during their first trimester of pregnancy. Differences in MoM values between a European reference group from a previous multicenter evaluation and the Asian population were evaluated. Two different types of population correction factors for T21 risk estimation were assessed.<br />Results: An at least 10% difference of median MoMs between European and Asian PAPP-A values was found to be statistically significant (p < 0.0001). The specificity of the screening did not show a big difference in individual countries, when using the country-specific correction factor compared with the overall Asian correction factor (<1.4%).<br />Conclusions: The use of a correction factor is recommended based on the differences in European and Asian MoM values. Developing country-specific medians in larger study populations can help identify clinical relevant differences and give the opportunity to explore a more accurate risk calculation.<br /> (© 2015 John Wiley & Sons, Ltd.)
- Subjects :
- Adolescent
Adult
Asia
Biomarkers blood
Down Syndrome ethnology
Europe
Female
Gestational Age
Humans
Middle Aged
Pregnancy
Pregnancy Trimester, First ethnology
Reference Values
Risk Assessment
Sensitivity and Specificity
Young Adult
Asian People
Chorionic Gonadotropin, beta Subunit, Human blood
Down Syndrome diagnosis
Maternal Serum Screening Tests
Pregnancy Trimester, First blood
Pregnancy-Associated Plasma Protein-A metabolism
White People
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0223
- Volume :
- 35
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Prenatal diagnosis
- Publication Type :
- Academic Journal
- Accession number :
- 25858516
- Full Text :
- https://doi.org/10.1002/pd.4602