Copper-catalyzed tandem phosphination-decarboxylation-oxidation of alkynyl acids with H-phosphine oxides: a facile synthesis of β-ketophosphine oxides.

Authors :: Zhang P
Zhang L
Gao Y
Xu J
Fang H
Tang G
Zhao Y
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2015 May 07; Vol. 51 (37), pp. 7839-42.
Publication Year :: 2015
Abstract: The general method for the tandem phosphination-decarboxylation-oxidation of alkynyl acids under aerobic conditions has been developed. In the presence of CuSO4·5H2O and TBHP, the reactions provide a novel access to β-ketophosphine oxides in good to excellent yields. This transformation allows the direct formation of a P-C bond and the construction of a keto group in one reaction.

Subjects :: Catalysis
Decarboxylation
Molecular Structure
Organometallic Compounds chemistry
Oxidation-Reduction
Phosphines chemistry
Acids chemistry
Alkynes chemistry
Copper chemistry
Oxides chemistry
Phosphines chemical synthesis

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