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Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2015 Apr 07; Vol. 21 (13), pp. 4048-62. - Publication Year :
- 2015
-
Abstract
- A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans.
- Subjects :
- Adult
Bacteriological Techniques
Biopsy
Child
Colonoscopy
Combined Modality Therapy
Complex Regional Pain Syndromes diagnosis
Complex Regional Pain Syndromes microbiology
Crohn Disease diagnosis
Crohn Disease microbiology
Female
Humans
Male
Mycobacterium avium subsp. paratuberculosis isolation & purification
Paratuberculosis diagnosis
Paratuberculosis microbiology
Paratuberculosis transmission
Remission Induction
Treatment Outcome
Young Adult
Antitubercular Agents therapeutic use
Complex Regional Pain Syndromes therapy
Crohn Disease therapy
Mycobacterium avium subsp. paratuberculosis drug effects
Mycobacterium avium subsp. paratuberculosis radiation effects
Paratuberculosis therapy
Ultraviolet Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 21
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25852293
- Full Text :
- https://doi.org/10.3748/wjg.v21.i13.4048