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Effect of gender on the response to a high fat diet in aging Fischer 344 rats.
- Source :
-
The Journal of nutrition [J Nutr] 1989 Oct; Vol. 119 (10), pp. 1472-7. - Publication Year :
- 1989
-
Abstract
- The purpose of this study was to describe the effects of high fat (HF) and low fat (LF) diets in male and female Fischer 344 (F344) rats ages 5, 23 and 27 mo. Rats were fed the diet for 3 mo, and then resting metabolic rate, body composition and adipose tissue cellularity were evaluated. Although body mass was greater in rats fed the HF diet, this difference was due to a rapid increase in mass within the first 2 wk. There was no difference in the rate of body mass gain after this period. Resting mass-independent metabolic rate did not significantly differ due to age, diet or gender. In general, percentage fat mass was greater in rats fed the HF diet and in female than in male rats in both diet groups. However, lean body mass (%) was not altered due to diet or age. Cell number of the retroperitoneal depot increased with age and diet between 5 and 23 mo of age in both male and female rats. There was no effect of age, diet or gender on retroperitoneal cell size or gonadal cell number and size. These data suggest that age, gender and diet do not significantly alter the ability of F344 rats to regulate body composition or fat cell proliferation.
- Subjects :
- Adipose Tissue drug effects
Adipose Tissue metabolism
Aging metabolism
Animals
Body Composition drug effects
Cell Count drug effects
Energy Intake drug effects
Energy Metabolism drug effects
Female
Male
Oxygen Consumption drug effects
Rats
Rats, Inbred F344
Sex Factors
Aging physiology
Dietary Fats administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3166
- Volume :
- 119
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 2585138
- Full Text :
- https://doi.org/10.1093/jn/119.10.1472